The next person on this list is the "McDreamy" star of one of the hottest shows on television, "Grey's Anatomy."
But Patrick Dempsey isn't letting success go to his head. He has seen it all before, and he knows that success -- like beauty -- can be skin deep.
But like Anna Wintour, Dempsey gets a lot of questions about … his hair.
"Everybody teases me about it," he joked. "And I tease myself about it. It's a lot to manage. It's quite difficult to keep it controlled."
But it's more than his hair that keeps viewers tuning in: It's his vulnerability, sensitivity and boyish innocence that first made him a star almost 20 years ago in the '80s classic "Can't Buy Me Love."
But stardom was short-lived, and Dempsey said that makes him appreciate what he has now. Next month, he gets his movie star status back with Hilary Swank in "Freedom Writers," and offscreen, he is married to hairstylist Jillian Fink. They have a 4-year-old daughter, Tallulah, and are expecting twin boys this spring.
Dempsey told Walters that being a heartthrob is better the second time around.
"I prefer this age … I don't think you care as much … I have had the alternative, and that's not any fun at all."
And the Most Fascinating Person of 2006? Walters revealed her choice on the special, and taking the top spot was the most fascinating person on election night this past November: Nancy Pelosi.
In January, Pelosi will become the most powerful woman in America, the first female Speaker of the House. She told Walters that becoming the first female Speaker "really is big:"
"The response that we have gotten from all over the country, from fathers and daughters, from just everyone, has been tremendous," she said.
And she had this to say about how she sees herself:
"Well, first of all, I would describe myself as a wife and mother. And grandmother but now I like Speaker of the House."
We asked you to vote for who you thought was most fascinating person this year. We received more than 8,000 votes, and more than 4,000 of you thought it was Barack Obama. Nancy Pelosi came in second, in a virtual tie with Stephen Colbert.