From the start, Knox's family has displayed unwavering support and proclaimed her innocence. But public opinion immediately turned against Knox, who was painted as a sex-crazed, party girl gone wild. Knox's father Curt Knox says this portrayal is "180 degrees opposite of anything we have ever known her to be."
Twice a week for the past three months, at least one of Knox's parents has visited her in prison, where she can be held for up to a year without even being charged, according to Italian law. Knox's father says that "being a young kid, she just doesn't understand -- why am I here when I didn't do anything."
"20/20" brought in Joe Tacopina, a high-profile New York criminal defense attorney who also has law offices in Italy, to analyze the case, which has been plagued by speculation.
"This case, like many high profile cases that garner a lot of media attention, is larded with non-truths and rumors that sort of take on a life of their own," he said.
Tacopina was given unprecedented access to both the prosecution and defense, and offers new insight and clarification of key evidence.
While the investigation continues, Amanda Knox's family hopes she will be released. Her sister, Deanna, who visited Knox twice just before Christmas, simply wants her back.
"One of the hardest things I had to deal with when I went to Italy was that after our little hour of seeing her, I had to watch her being taken away," Deanna Knox said. "I didn't want to let go. I just wanted to take her home with me."