The Emmy winner and "Veep" star was on hand to root for her son, Charlie Hall, who plays for Northwestern.
Breaking down a bit in happiness, she mouthed "Oh my God" as her son's team pulled off the nail-biter.
Louis-Dreyfus, 56, has been very vocal about her baby boy and his "March" to greatness.
Who can forget her breaking out the "Elaine dance" after the team was selected to the field.
"We're going to the dance, boys! @NUMensBball making history! #proud #B1GCats #poundtherock #NCAA @marchmadness," she wrote.
It's going to be an exciting two weeks for sure! The Wildcats next play the top seed in their region, Gonzaga, on Saturday.