"Can you believe this? Representative Ball is criticizing Congressman Weiner. Your move, Mayor Scrotum," he joked again.
And he joked some more: "I have to ask this: 'What kind of world are we living in when porn stars make Weiners go down?' It's reverse world."
Then, there were jokes about the photos.
From Jimmy Fallon: "At a press conference this afternoon, Congressman Anthony Weiner admitted that he tweeted out that photo of his crotch. During the press conference, Congressman Weiner was choked up and got a lump in this throat -- not as big as the lump in his underwear, but still, very emotional."
"View" co-host Joy Behar on Twitter: "Hard to tell from photos if Anthony Weiner is well-endowed. They say the camera adds ten pounds."
David Letterman: "I don't know if laws were broken or not, but Weiner was sending around pictures of him in his underpants and I thought, Well, now, wait a minute, what is the big deal? Don't men and women in Congress get to mail their packages for free?"
And Jay Leno: "With all this new media, is that considered junk e-mail? Or is it e-mail of your junk? There are so many terms."
Bill Maher put the scandal in context with other sex scandals involving politicians.
"Thanks to you, Congressman Weiner, there is now a new low in what passes for a sex scandal," he said. "JFK got Marilyn Monroe. John Edwards got a love child. You got mail."