Post-"Friends," Aniston has had her share of box office hits, "Marley & Me" and "The Break-Up," and romantic comedy misses, "He's Just Not That into You" and "Rumor Has It." She has successfully made the leap from the small to the big screen and has frequently made Forbes' lists for her fame and earnings.
There has been much buzz around her new movie, "Horrible Bosses," where Aniston will reportedly play a sex-crazed dentist -- a vast departure from her "Friends" character Rachel Green. Aniston's rep told People magazine that the role requires "an aggressive sexuality that many folks have not seen from Jennifer on screen before."
For Aniston, it's her personal life that has seemed to eclipse her professional life. Aniston, now 41, has made headlines for posing provocatively on the covers of magazines. When she appeared nude on the cover of GQ in January 2009, she told the magazine she feels more comfortable with herself now than in her 20s or early 30s. "I'm healthier. I'm more at peace in my mind and with my body," she said.
She also seems to have made peace with her breakup with Brad Pitt. After their five-year storybook marriage ended, Pitt began seeing Angelina Jolie. While Pitt and Jolie may or may not be ensconced in domestic bliss, with their six children, Aniston has been linked with several different men, including "Bounty Hunter" co-star Gerard Butler, Vince Vaughn, John Mayer, and model Paul Sculfor.
Schwimmer has spent much of the last six years out of the limelight, working with his small theater group, the Lookingglass, in Chicago and trying to launch a career as a movie director.
He has had limited success as a director. His 2007 film "Run, Fat Boy, Run," a British romantic comedy, bombed at the box office, but USA Today said Schwimmer possessed filmmaking finesse "having wisely chosen strong comic material for his debut behind the camera." He also reportedly met his soon to be wife during the making of the film.
In front of the camera, Schwimmer, 43, hasn't seen much action besides guest starring roles on "30 Rock" and "Entourage," where he played himself. Ironically, in the "Entourage" episode, agent Ari Gold tries to steer his career back to television.
But, according to the Daily Mail, Schwimmer has had to return to auditioning for parts, even while being turned down for top roles.
Perry, 40, has been unable to find his groove since playing Chandler on the hit sitcom.
His attempts to repeat his "Friends" success on the small screen have fallen flat. His 2006 series "Studio 60 on the Sunset Strip" was dropped by NBC after the first season because of poor ratings. Last year, he tried again to return to television as a radio talk show host in "The End of Steve," but the dark comedy was scrapped after just one episode.
Perry has had equally bad luck on the big screen. In his first film role after "Friends," Perry played a man a chronically depressed man in the 2007 movie "Numb." The film flopped at the box office. His most recent role in "17 Again" was better received, but he played second banana to star Zac Efron.
In the past, Perry has admitted to struggles with depression and alcohol and prescription drug addiction. Production on 2002's "Serving Sara" had to be shut down for three months while Perry checked into rehab.