Osmond became a champion for many mothers struggling with post-partum depression, and in 2005, chastized Tom Cruise when he lashed out at Brooke Shields for using anti depressants after the birth of her daughter.
"When Tom becomes a woman and has a baby and has postpartum, then he can become an expert," she told People magazine.
From anorexia to over-eating, Osmond has battled with body image from a young age. As a teenager on the "Donny & Marie" show, she was told to lose weight or lose her job.
"By the time I was 14, we did the pilot for the 'Donny & Marie' variety show, and I was down to about 110 pounds and feeling really thin," she told Oprah Winfrey in 2009. "Shortly after that, I was taken out into a parking lot by producers and told that if I didn't lose more weight, the show would be canceled. So I went from about 110 pounds to 93 pounds, which was absolutely stupid."
Osmond said she tried "everything from diet pills to starving myself to bulimia" to lose weight. But after giving birth to her last child in 1999, she began to indulge in food.
"All of a sudden, one day I woke up and I was no longer a size 2–4," Osmond told Winfrey, adding that in 2007, at her heaviest, she weighed 165 lbs. "I was a 12–14, and I couldn't see it in the mirror. I didn't want to see it."
Osmond dropped 45 lbs. with the help of the NutriSystem, the diet plan she endorses. She said her family inspired her to get healthy.
"I did it because my oldest boy came to me, and he was 23 at the time, and he said, 'All of us got together, Mom, and we love you, and we want you to be around for our kids, your grandkids,'" she told Winfrey.
Osmond's life in the limelight has made her and her family a tabloid target. In 2006, the National Enquirer reported that she had been hospitalized after a failed suicide attempt. But according to her representative, Amy Hawke, Osmond was only being treated for an "adverse reaction to some medication."
"We deal with those tabloids all the time," Karl Engemann, Osmond's manager, told The Associated Press at the time. "You get tired of responding. It's like punching Jell-O."
Osmond herself tried to punch back in 2009, when multiple blogs claimed her daughter, Jessica Blosil, was a lesbian. Osmond went on Los Angeles radio station KOST 103.5 to say that she and Jessica "have a great relationship and I think she would tell you that."
The last time tragedy struck her family, Osmond took it in stride. When her father, George, passed away at age 90 during her 2007 turn on "Dancing With the Stars," Osmond decided to continue competing in her father's memory.
Now, following the death of her son, the Las Vegas show Osmond headlines with her brother Donny has been suspended until further notice. It remains to be seen if the entertainment industry fixture will, literally, work through her pain again.