Buble was still hurting when he saw Lopilato walking across a parking lot after one of his shows. He immediately knew there was something special about her.
"I was going through a really rough time. I was really down," Buble said. "And I'll never forget it: I saw her and I turned to my grandfather and I had the strangest pain -- and I said to him, 'Grandpa, I have just seen the most beautiful woman that I have ever seen,' and, I said, 'And I'll never see her again.'"
But later, Buble's record company introduced the two.
"Hours later, I was doing the usual: I was drinking hard and, you know, trying to forget. I was trying to escape," he said. "I was sitting with my grandpa, and the record company came in and said, 'Would you mind meeting someone? She's our most famous actress.'"
He spoke no Spanish and she spoke no English, but Buble was smitten with Lopilato, especially after a friend she was with told him that she liked him.
"What I didn't know was that she was on the phone texting her mother, saying, 'I've come to meet Michael Buble. And this dude is gay. Gay,'" he said, laughing.
Now, three years later, the two are married with a baby on the way. But while they are excited to create a family together, making an album together is not on the horizon.
"I think never," Buble said. "Someone wanted me to record with her on this record ['To Be Loved'] and I was like, 'uh uh.' See, it's funny: I love having my wife here ... yet I think that working together in that way is terribly cringey."
But Buble did do a collaboration with another famous actress on "To Be Loved." After watching Reese Witherspoon play June Carter in the Johnny Cash biopic, "Walk The Line," Buble said he fell in love with the actress' voice and asked her to sing a duet with him on his new album. The two sing together on the sad, romantic song "Something Stupid," which Buble said is one of his favorite tracks on the album.
"I thought [Witherspoon] had a really wonderful dulcet sweet tone," he said. "She really understood the subtext of that song ['Something Stupid'] ... and when she sang it she believed it, and when you believe it the audience has to believe it."
Buble and Witherspoon are longtime friends and the singer said she was the first person outside of family to find out he and his wife were expecting a baby.
"She was just really pumped for me and really supportive," he said. "She was just squealing with delight for me and telling me how excited she was."
Witherspoon recently made headlines when she was arrested for disorderly conduct after she became upset her husband was pulled over for driving erratically. Witherspoon later publically apologized for her behavior, and Buble said he thought she handled herself with poise.
"I only hope that if I get into trouble, and when I get in trouble, that I handle myself with such grace and dignity," he said.
So what is next for the singer with the golden voice? Obtaining something Buble said he will never get.
"I will never get critical acclaim," he said. "There's nothing cool about liking a guy who's sold 40 million records. It's cool to like someone who's sold 5,000. Who's the indie star, who's the underdog. That's cool, that's hip. I just need to take solace in the fact that I don't make records for the critics. I make records for people, and the greatest review I can get is when somebody pays their money across that counter and buys one of my records. And that's something that I can live with."