Five U.S. presidents have appeared on the show: Jimmy Carter, George H. W. Bush, Bill Clinton, George W. Bush and Barack Obama.
The total number of items selected as "Oprah's Favorite Things": 283.
Winfrey and her show have won a total of 48 daytime Emmys.
In 25 years, about 1.3 million people have been in the studio audience for her show. For the final season, about 1.4 million people have requested tickets.
The audience for Tuesday's event at the United Center may not have been the largest for a taping of "The Oprah Winfrey Show." That distinction goes to the Season 24 "Kickoff Party" in 2009, when about 21,000 people closed down Chicago's Michigan Avenue to watch the Black Eyed Peas, Jennifer Hudson, Rascal Flatts and James Taylor.
A total of 65 books became Oprah's Book Club selections and nearly 2 million people joined Winfrey's book club.
More than $80 million has been donated to Oprah's Angel Network.
ABC News' Angela Ellis and Andy Fies contributed to this story.