With Rob Lowe Out of the Running, Who Should Replace Charlie Sheen?

VIDEO: Charlie Sheens career hangs in the balance under glare of media attention.

Rob Lowe has no love for "Two and a Half Men."

Despite Charlie Sheen's assertations that Lowe is "a beautiful man" and would make a "fabulous" potential replacement for him on "Two and a Half Men," at a panel in Los Angeles on Wednesday, "Parks and Recreation" executive producer Michael Schur revealed that Lowe has signed a "multiyear contract" with his show.

Schur added that "there's no truth" to the rumors that Lowe will replace Sheen. "The Internet lit a match and set itself on fire," he said, according to The Hollywood Reporter.

On fire indeed. Many online commenters wouldn't mind if Lowe -- or John Stamos, another name that's been bandied about -- stepped into Sheen's shoes. Sheen gave both actors a thumbs up in an interview on Dan Patrick's radio show Wednesday and offered them -- or whoever his successor may be -- some advice:

"What I would advise them to do, though, is just make it their own," Sheen added. "Don't, don't, don't think about anything that I've done brilliantly on the show for 177,000 episodes … but I would just tell them, make it your own."

Indeed, "Two and a Half Men" creator Chuck Lorre crafted the Charlie Harper character for Sheen, not for any other actor. Do both love to drink? Check. Both drawn to multiple women at a time? Check. Both prone to fits of rage? Check.

But surely a man not fueled by "tiger blood" or built with "Adonis DNA" could play the similarly-minded uncle, cousin, long lost best friend or secret half-brother of TV's most loved playboy. (Isn't that why they call it acting?) Considering the studio suits probably have their hands full with threats from Sheen's lawyer and the potential loss of hundreds of millions of dollars of revenue, we thought we'd throw them a line.

Below, 10 potential replacements for Sheen on "Two and a Half Men:"

Rob Lowe

Rob Lowe. Relation to Charlie Harper: cousin. Why him? Fine, he's out of the running. But the guy's got range. He recently went from playing a senator ("Brothers & Sisters") to a drug-and-danger loving actor ("Californication") Tiger blood relative seemed like a logical next step.

Jason Alexander

Jason Alexander. Relation to Charlie Harper: uncle. Why him? He really, really wants it. "Seinfeld's" erstwhile George Costanza posted a series of tongue-in-cheek tweets Monday saying he's willing to go the distance to embody Sheen.

"I will commence using cocaine in quantities large enough to challenge the national output of Columbia; fornicate with as many adult film actresses as I can afford," Alexander wrote, "commit assaults in four and five star hotels prior to trashing the hotel rooms; and finally strive to alienate and piss off not only my immediate bosses and superiors, but the entire film and television industry."

John Stamos

John Stamos. Relation to Charlie Harper: long lost (and better looking) best friend. Why him? He's played the bad boy in the family sitcom before. As "Full House's" Uncle Jesse, he inspired countless teenage girls to pursue relationships with pompadour-haired, motorcycle-riding crooners.

Plus, he was the first candidate to win Sheen's approval. After Sheen first that Stamos would be a "tragic joke" on the show, he dialed back his comments: "I was out of line and you're a beautiful man, and a talented man," Sheen said last week. "If you get the gig, we should talk."

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