The ghost-face killer is back, and with him, another round of panting, slashing, and blood-curdling shrieks galore.
Like the "Screams" that came before it, much of the latest movie has been kept under wraps. On set, director Wes Craven took steps to ensure that the cast didn't divulge details of the plot with tweets and texts.
"We took everyone's cell phones," Craven told The Associated Press. "We made them sign non-disclosure agreements, and we went on the Internet and watched all night to see who posted what. ... By and large, people honored our plea to keep it a secret."
Internet leaks were something Craven probably worried less about in 1996, when the first installment of the slasher-film franchise came out.
What's the cast of the original "Scream" up to now? ABCNews.com takes a look at what they're doing, below:
Courteney Cox. When Cox, 46, first appeared in "Scream," she was best known as Monica Geller, the neat-freak chef on "Friends." Now, it's hard to peg her as just one thing. Besides reprising her role as tabloid reporter Gale Weathers in "Scream 4" (as she did in "Scream 2" and "Scream 3") she stars in the ABC comedy "Cougar Town," and formerly co-executive produced and starred in the FX series "Dirt."
"Scream 4" puts Cox back on screen with David Arquette, the man she met while filming the first "Scream," later married and had a child with. In October, they separated.
Cox told Entertainment Weekly that while things were sometimes awkward on set, she and Arquette are on good terms now.
"I would say we're probably better now than we were during that movie," she said. "The movie was just a little bit of a tough time. I don't have the fondest memories of those particular moments during that film."
In an interview on Howard Stern's radio show Thursday, Cox revealed that Arquette's appetite for sex spoiled their marriage, saying he "could not literally put his arm around me for one second without getting [an erection]."
David Arquette. Arquette scored his most memorable role with "Scream," playing Det. Dewey Riley. After that, his Hollywood endeavors mainly were limited to "Scream's" sequels. Arquette explored the realm of professional wrestling while dabbling in TV projects (he was Cox's co-executive producer on "Dirt") and frequently guesting on Howard Stern's radio show. For the most part, he seemed happy to focus on Cox and their daughter.
That changed in October when Arquette and Cox separated and he spiraled downward, eventually entering a rehab treatment center in January and suffering a car crash in March. Now he's on the mend. Earlier this month, Arquette, 39, celebrated more than 90 days sober by dancing on stage at a concert in Chile.
Neve Campbell. The '90s were good to Campbell: She was a regular in a hit TV show, "Party of Five" and starred in a slew of movies, including playing death-defying Sidney Prescott in the "Scream" series, "The Craft" and "Wild Things."
In the last decade, she's taken on lower-profile projects like the 2004 indie film "When Will I Be Loved," which received rave reviews but had a brief theatrical run. She also divorced her first husband, re-married, and divorced again.
Now 37, she's got more perspective on life. Asked what advice she'd give to herself at 23 (her age when she filmed "Scream"), Campbell told iVillage.com, "Relax! I would have wanted to understand that I should be less concerned with what people think."
Drew Barrymore. "Scream" made waves by killing off its most famous cast member, Barrymore, in the film's opening scene. Getting offed made it pretty much impossible for Barrymore to reappear in the "Scream" sequels, but the 36-year-old actress had an illustrious career to keep her busy. The production company she founded in 1995, Flower Films, put out a string of hits, including "Never Been Kissed" and "Charlie's Angels." Barrymore established herself as a romantic comedy staple with films like "The Wedding Singer" and "50 First Dates."
She branched out from blockbuster fare as well. In 2010, Barrymore scored SAG and a Golden Globe awards for her portrayal of Little Edie in the HBO miniseries "Grey Gardens."
As one of Hollywood's most-coveted actresses, Barrymore's personal life often makes headlines. She briefly was married to the comedian Tom Green last decade and recently had an on-again, off-again relationship with Justin Long, her co-star in "Going the Distance." She's most recently been linked with writer Will Kopelman.
Jamie Kennedy. Kennedy played Randy Meeks in the original "Scream," the computer whiz who taught everyone the rules of surviving a horror film (i.e., "You can never have sex"). Alas, his character met his end in the sequel.
Since then, Kennedy has focused on comedy, starring in "Malibu's Most Wanted" alongside Kal Penn. He produced and appeared in shows including "The Jamie Kennedy Experiment," "Blowin' Up," and "The Starlet." After a brief romance with fellow '90s fixture Jennifer Love Hewitt (the two acted together on Hewitt's series, "Ghost Whisperer"), Kennedy is single again.
Now 40, he recently reflected with Entertainment Weekly on shooting the first "Scream."
"I'm a night person, so shooting at night was very cool, and we had shot for like two and a half weeks straight at night," he said. "I think it was scene 142, it was called -- it was the lengthiest scene in Wes [Craven's] career. It was the big killing scene, and it was just crazy."
Rose McGowan. McGowan's character, Tatum Riley, suffered one of the most gruesome deaths in "Scream," meeting her end in a garage door.
The actress, on the other hand, has had a pretty swell run since then. She won acclaim for 1998's dark comedy "Jawbreaker" and went on to star in the TV series "Charmed." More recently, she headlined the Quentin Tarantino/Robert Rodriguez feature "Grindhouse" in 2007.
McGowan was half of one of the most eye-catching couples of the '90s. She and rocker Marilyn Manson dated from 1998 to 2001, but split because of "lifestyle differences," according to a statement McGowan made following their breakup. In 2007, McGowan got engaged to "Grindhouse's" Rodriguez but they split in 2009.
The 37-year-old actress is also a dog lover and activist for Boston terriers. She has two of her own and advocates on behalf of the animal saving organization Boston Terrier Rescue Net.
Skeet Ulrich. The mastermind of "Scream," Ulrich played Billy Loomis, Sidney's murderous boyfriend who eventually gets what's coming to him. That's probably his best known role.
Now 41, Ulrich's credits include starring alongside Cuba Gooding Jr. in "Chill Factor" and a small part in "As Good as It Gets." He signed on to the new series "Law & Order: Los Angeles" but was released from his contract after 11 episodes.
Matthew Lillard. With his ability to contort his face in "Mask"-like ways, Lillard was perhaps the funniest member of the original "Scream" cast. His character, Stu Macher, was in cahoots with Billy to kill Sidney and her cohorts. Like his pal, Stu got slashed in the final scenes of "Scream," rendering Lillard unable to be cast in the film's sequels.
After appearing in "SLC Punk," Lillard, now 41, distanced himself from Hollywood to have a family. He most recently played Shaggy in 2002's "Scooby-Doo."