In the last decade, she's taken on lower-profile projects like the 2004 indie film "When Will I Be Loved," which received rave reviews but had a brief theatrical run. She also divorced her first husband, re-married, and divorced again.
Now 37, she's got more perspective on life. Asked what advice she'd give to herself at 23 (her age when she filmed "Scream"), Campbell told iVillage.com, "Relax! I would have wanted to understand that I should be less concerned with what people think."
Drew Barrymore. "Scream" made waves by killing off its most famous cast member, Barrymore, in the film's opening scene. Getting offed made it pretty much impossible for Barrymore to reappear in the "Scream" sequels, but the 36-year-old actress had an illustrious career to keep her busy. The production company she founded in 1995, Flower Films, put out a string of hits, including "Never Been Kissed" and "Charlie's Angels." Barrymore established herself as a romantic comedy staple with films like "The Wedding Singer" and "50 First Dates."
She branched out from blockbuster fare as well. In 2010, Barrymore scored SAG and a Golden Globe awards for her portrayal of Little Edie in the HBO miniseries "Grey Gardens."
As one of Hollywood's most-coveted actresses, Barrymore's personal life often makes headlines. She briefly was married to the comedian Tom Green last decade and recently had an on-again, off-again relationship with Justin Long, her co-star in "Going the Distance." She's most recently been linked with writer Will Kopelman.
Jamie Kennedy. Kennedy played Randy Meeks in the original "Scream," the computer whiz who taught everyone the rules of surviving a horror film (i.e., "You can never have sex"). Alas, his character met his end in the sequel.
Since then, Kennedy has focused on comedy, starring in "Malibu's Most Wanted" alongside Kal Penn. He produced and appeared in shows including "The Jamie Kennedy Experiment," "Blowin' Up," and "The Starlet." After a brief romance with fellow '90s fixture Jennifer Love Hewitt (the two acted together on Hewitt's series, "Ghost Whisperer"), Kennedy is single again.
Now 40, he recently reflected with Entertainment Weekly on shooting the first "Scream."
"I'm a night person, so shooting at night was very cool, and we had shot for like two and a half weeks straight at night," he said. "I think it was scene 142, it was called -- it was the lengthiest scene in Wes [Craven's] career. It was the big killing scene, and it was just crazy."
Rose McGowan. McGowan's character, Tatum Riley, suffered one of the most gruesome deaths in "Scream," meeting her end in a garage door.
The actress, on the other hand, has had a pretty swell run since then. She won acclaim for 1998's dark comedy "Jawbreaker" and went on to star in the TV series "Charmed." More recently, she headlined the Quentin Tarantino/Robert Rodriguez feature "Grindhouse" in 2007.
McGowan was half of one of the most eye-catching couples of the '90s. She and rocker Marilyn Manson dated from 1998 to 2001, but split because of "lifestyle differences," according to a statement McGowan made following their breakup. In 2007, McGowan got engaged to "Grindhouse's" Rodriguez but they split in 2009.
The 37-year-old actress is also a dog lover and activist for Boston terriers. She has two of her own and advocates on behalf of the animal saving organization Boston Terrier Rescue Net.