Many big performances are on the bill. Tony Bennett and Billy Joel will sing their Grammy-nominated duet "New York State of Mind" as a tribute to the victims of Sept. 11. You'll also hear country superstar Alan Jackson perform his hit inspired by the attacks, "Where Were You (When the World Stopped Turning)."
There will also be tributes to stars who died in 2001, including Aaliyah and George Harrison.
Al Green, Brian McKnight and India.Arie will go a gospel melody, while country artists Emmylou Harris, Alison Krauss, Ralph Stanley and Gillian Welch will perform traditional bluegrass numbers from the O Brother Where Art Thou soundtrack.
You'll also see the Lady Marmalade girls — Christina Aguilera, Lil' Kim, Mya and Missy Elliott in a huge production number with Patti LaBelle.
One artist you won't see: Michael Jackson. After weeks of controversy, Jackson decided that he will not be performing.
In January, Michael backed out of performing on the American Music Awards, reportedly because he had been told if he did, he couldn't perform on the Grammys. That prompted AMA producer Dick Clark to sue Grammy boss Mike Greene for $10 million.
Jackson later agreed to provide a video of himself performing his classic hit "Man in the Mirror." But he later pulled the clip.
Jackson, who is nominated for best pop male vocal performance for "You Rock My World," is no longer slated to perform, and it's unclear whether he'll even show up.
ABCNEWS Radio and ABCNEWS.com's Buck Wolf contributed to this report.