Among the other nominees, Patricia Arquette of "Medium" is the only first-timer. It's an impressive field that includes Frances Conroy ("Six Feet Under"), Jennifer Garner ("Alias") and Mariska Hargitay ("Law & Order: Special Victims Unit").
Supporting Actor, Drama Series: Just call Alan Alda "Mr. Emmy." The former "M*A*S*H" star has wracked up 25 nominations and five wins. His latest is for his work on "West Wing" as a Republican senator with presidential aspirations -- a performance not too far off from his role last year in "The Aviator," which earned the 69-year-old actor his first Oscar nod.
Another classic TV star, William Shatner, is also in the mix. Shatner's bombastic senior partner Denny Crain on ABC's "Boston Legal" is galaxies away from Capt. Kirk. But "Boston Legal" has yet to find the audience that other David E. Kelley legal dramas have enjoyed.
Award shows love comeback stories, but Alda and Shatner are going to have a tough time beating Terry O'Quinn -- a standout on "Lost" -- even if he must battle fellow cast member Naveen Andrews. Also nominated is Oliver Platt of "Huff."
Supporting Actress, Drama Series: "West Wing's" Stockard Channing has been nominated six consecutive years. She took home the trophy in 2002, but it's hard to make the case that she'll be honored again. If Channing has been at it too long to impress voters, Sandra Oh of "Grey's Anatomy" might have the exact opposite problem. Her show premiered in March, and less than a full season of work might not be enough to garner a victory.
This might leave Blythe Danner of Showtime's "Huff" in a good position. Danner is up for three Emmys this year, including one as best guest actress in a comedy series for her turn as Will's mom on "Will & Grace." In real life, Danner is Gwyneth Paltrow's mom, and she got a lot of exposure for her work in the box office hit "Meet the Fockers."
Other nominees: Tyne Daly of CBS' "Judging Amy" and CCH Pounder of FX's "The Shield."
Actor, Comedy Series: Two Emmy newbies -- Jason Bateman ("Arrested Development") and Zach Braff ("Scrubs") -- face off against three perennials -- "Monk's" Tony Shalhoub, "Will & Grace's" Eric McCormack, and the man who virtually can't lose, Ray Romano.
Romano has two wins and 13 nominations, and will probably receive one more parting gift. McCormack, a four-time nominee, took home the prize in 2001, while Shalhoub, a three-time nominee, got his in 2003.
Actress, Comedy Series: It's a catfight on Wisteria Lane. Marcia Cross, Teri Hatcher and Felicity Huffman of "Desperate Housewives" face off against each other. If they split the vote, either Patricia Heaton of "Everybody Loves Raymond" and "Malcolm in the Middle's" Jane Kaczmarek could be a factor.
Supporting Actor, Comedy Series: There's nothing Hollywood loves more than itself. And that's good news for Jeremy Piven, the snarky superagent Ari Gold on HBO's "Entourage."
Two of Piven's rivals -- Peter Boyle ("Raymond") and Jeffrey Tambor ("Arrested Development") -- fall in the "always a bridesmaid" category. Boyle is zero-for-seven and Tambor is making his fifth bid, after four nominations for his stint on "The Larry Sanders Show."
The other two nominees are former winners -- Sean Hayes ("Will & Grace") and Brad Garrett ("Raymond") -- and both of them have created characters that will live forever in TV's pantheon of wacky sitcom characters. But it's unlikely they'll win again.
Supporting Actress, Comedy Series: Doris Roberts has three-peated as "Raymond's" overbearing mom. Could she have one more win in her pantry? Could Mullally, a six-time nominee, get a second taste of glory as "Will & Grace's" vodka-and-Prozac-swilling Karen Walker?
Perhaps the best bet is "Two And a Half Men's" Holland Taylor, who plays Charlie Sheen's socialite mother. The CBS show has consistently scored high ratings, and Taylor's castmate, Conchata Ferrell, is also nominated. "Arrested Development's" Jessica Walter is also in the running.