But Yankee Stadium didn't just host games for its pinstriped team; it also was the home of big boxing matches with Joe Lewis, Rocky Marciano and Muhammad Ali. The 1958 NFL championship played out there when the Baltimore Colts beat the New York Giants.
It's hosted Popes, presidents, preachers and pop stars.
When the terror attacks of Sept. 11, 2001 shook the nation, it's where fans found their solitude, as President Bush threw out the first pitch while wearing a FDNY jacket in the first game after the incident.
Many Bronx residents see the area as hallowed ground and about much more than mere baseball.
"It's just very heartfelt to see our team leave this building which is really historic," said Bronx resident and Yankee fan Rachelle Feldman.
Now the fans and the stadium must make way for a new sports ground, which will be completed in time for the 2009 season. But the memory of this Yankee Stadium already has assured its place in the history books.