Exclusive: Caylee Anthony's Grandparents on Natalee Holloway, Joran Van der Sloot

On the second anniversary of Caylee Anthony's disappearance, the toddler's grandparents said they can identify with Natalee Holloway's mother, but not with the mother of suspected murderer Joran van der Sloot -- despite the murder charges against their daughter, Casey Anthony.

"I don't know if I can identify with Mrs. Van Der Sloot because her son has confessed to something," Caylee's grandmother, Cindy Anthony, said in an exclusive interview with "Good Morning America." "You know, there have been issues where she saw his angry side. I don't know that of Casey. I don't know Casey as being anybody that could hurt anybody."

VIDEO: Joran Van Der Sloot Charged With Murder
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CLICK HERE to read our full report on the "GMA" exclusive interview with George and Cindy Anthony.

Casey Anthony is charged with murdering her daughter, 2-year-old Caylee Anthony. The Florida toddler disappeared in June 2008, but Casey did not report the child missing until a month later. In October she was formally charged with the little girl's murder and in December, Caylee's body was found less than a mile from the Anthony home.

Casey Anthony pleaded not guilty and is expected to go to trial in May 2011. The Anthony family has maintained that Casey is innocent

CLICK HERE to see ABC News' Casey Anthony Case TIMELINE.

Natalee Holloway disappeared five years ago on the Caribbean resort island of Aruba. Van der Sloot, recently charged in a separate murder in Lima, Peru, was the prime suspect in the Holloway case.

Anthonys Met Holloway's Mother in 2008

Cindy Anthony said that Holloway's mother, Beth Twitty, met the Anthonys in August 2008, three years after Natalee went missing and two months before Casey was charged with Caylee's murder.

"She wanted to share some of the things that she had been through and her heart was breaking for us," Cindy said. "And my heart breaks for her."

However, she said she only feels "numb" for van der Sloot's mother.

"I can't make judgement because I don't know what she's feeling," Cindy said. "I don't identify with her. I really don't."

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