"This is a really good man who really did a very bad thing," she told Oprah. "I have a husband who adores me, who is unbelievable with my children, who has in times when I've been in enormous pain with the death of Wade or with cancer, has been by my side."
With John and Elizabeth Edwards declining to comment further on their relationship, it's unknown if the sentiment survived the latest onslaught of scandal headlines.
Friends have said that the couple is living apart, but John and Elizabeth Edwards have not confirmed the claim.
Jennifer Palmieri, a former aide to the Edwards campaign, called Elizabeth Edwards "opinionated, unyielding, blunt and unwilling to suffer fools," in an article Palmieri wrote for The Washington Post.
"Saint Elizabeth she is not," Palmieri wrote. "And no one laughs louder than she at that notion. But she is also one of the wisest, warmest and funniest girlfriends a woman could hope to have, truly a call-her-in-the-middle-of-the-night-and-she-will-drop-everything-to-help sort."
In recent days, Palmieri said Elizabeth Edwards appeared "grounded, funny, maybe even happy."
"When I spoke with her this week, I thought that for the first time in three years the old Elizabeth seemed to be back," she said.