The day after she reported the child missing, Anthony was arrested on charges including child neglect. During a bond hearing July 22, authorities named Anthony a "person of interest" in Caylee's disappearance and said they were treating the case as a potential homicide after they discovered "evidence of decomposition" in the trunk of a car that Anthony had driven.
On Oct. 14, with Caylee's body still missing, Anthony was officially charged with first degree murder.
By the time Kronk found a child's remains less than half a mile from the Anthony home Dec. 11, the massive search effort had attracted thousands of volunteers. Authorities including the FBI had tracked down hundreds of leads both in the United States and abroad.
Eight days later authorities confirmed through DNA testing that the remains belonged to the missing toddler.
It has been the defense's position throughout the search that Anthony "handed [Caylee] up to a third party" in June and that a body could be found, Todd Black, spokesman for Anthony's attorney Jose Baez, told ABC News after the remains were found in December.
"From the beginning he [Baez] started preparing for the worst, but hoping for the best," Black said.
Anthony claimed a woman named Zenaida Fernandez-Gonzalez who was Caylee's nanny was the last person to see Caylee alive after Anthony dropped Caylee off at her apartment. After an extensive search for Fernandez-Gonzalez, one woman came forward to deny any involvement in the case or any connection with the family at all.
Police cleared Fernandez-Gonzalez, 37, and the woman filed a defamation lawsuit against Anthony in September, claiming she lost her job and cannot find an apartment because of her inclusion in the investigation.
Andrea Canning contributed to this report.