Extreme Weight Loss: Diets, Exercise Plans That Change Lives

I put my health on the back burner. And I think it caught up to me. Reporter: At 25 years old and 288 pounds, ashley donahue was depressed. I was unhappy with my job. I was unhappy with the way my... See More

I put my health on the back burner. And I think it caught up to me. Reporter: At 25 years old and 288 pounds, ashley donahue was depressed. I was unhappy with my job. I was unhappy with the way my life was going. I had a hard time enjoying the little things my kids wanted to do. My health was failing. My doctor told me, he didn't think I would make it to 30 if i kept on. It kept getting worse and worse. Reporter: It was her faithful husband that got her back on the path to health. I think his heart was breaking physician me. And he saw how unhappy I was. He came to me and said, we're going to go for a walk. On that walk, she started thinking about her own heart. The realization hit me that i made the choice to get where i am right now. So, I'm going to make a different choice. I don't feeling or being that big. Reporter: Caroline's struggles began early. At 8 years old, she was already 120 pounds. And the medical weight loss program she was put on didn't help. I found a way to get a foo hustler. And get whatever food I wanted. I was hungry. My peers, they taunted and teased me. I didn't go to my prom. I never had dates. Wasn't able to do something things like ride a rollercoaster because the safety bar wouldn't go over my stomach. Reporter: She remained heavy until college. At her heaviest, 303 pounds, when she started feeling self-conscious. I started feeling like all of these difficult self-choices were a huge pause button for myself. And I said, I'm tired of this. I want to have a normal life. Reporter:33-year-old lea found herself at 251 pounds, after two pregnancies. I tended to be an emotional eater. I wanted the food. It made me feel good. And so, I ate it. Reporter: It was her chiren that helped her turn it around. Thinking about going out to the park with my kids felt like work to me. And at some point, I realized, that's ridiculous. Not only am I cheating myself. But I'm cheating my kids of me. I walked into a jenny craig center. And I haven't looked back ever since that day. I was, like, lea's getting her