Transcript for Rob Lowe on Why He Turned Down McDreamy Role
This is technology. Happy birthday. Have a seat. Thank you. New memoir called "Love life." It came out today. I have to tease you a little bit. We read "The New York times" on Sunday. Rob Lowe on the problems with being pretty. There's an unbelievable bias and prejudice against quote/unquote good-looking people. George, you're the perfect journalist to bring this to light. Worldwide, a minimum of 20 or 30 people suffer from this. You know -- if I can't use my podium for good, what's the point of it, really? You are a selfless guy. That's what we always say. Thank you so much. Let's talk about this a little bit. The book is fantastic. I don't know how you keep on coming up with so many great stories. I got to tell you -- I'll confess. I went right to the middle and went to rob Lowe's trip to the playboy mansion. 19 years old. Can you imagine? Where were my parents? 19 years old, playboy mansion. What I love about books like this. I'm a fan of the genre. I like a book that doesn't take me to a place I normally get to go. How many people get to go, in the '80s, when it was crazy. This was the zietgiestest place. I decided to put it in the book. And you talk about missteps that you made. And I had not heard this one before. You had a chance to go on "Grey's anatomy." The job of Patrick Dempsey. And you said no way. I tell that story. I'm talking about how actors and all people, come to places in their lives and they have a choice. Do they make the right choice? Do they make the wrong choice? What goes into making those choices? What's in that story is the thought process I had when I chose a different show over that. And it's called "Wish sandwich." One of my favorite chapters. And great stories about Amy Adams, embedded in the same way. Showing that failing, not getting something, can be the best thing in the world for you. She was supposed to play your love interest. She was my love interest. The show was canceled. We were sad when it went that way. But only because it was canceled, was she available to get the job that got her an Oscar nomination. "June bug." "June bug" started her out. And the love life lesson, even though it seems bad, it's really good. You just don't know yet. One question came in, if you weren't an actor, what would you do in your life? I would have gone to law school. I love law. I love public service. I might have had your early job. A real one. Someone is saying "The west wing" may be coming back? If only. Oh, my gosh, that would be so great. I heard nothing about that. I would be in makeup and hair immediately. You had fun with that show. And talked to Lara about turning 50. I'm a few years ahead of you. But a few years behind you on something else. You write about this in the book, as well. It's very moving. You said, so long, your son is on the way to college. Brutal. Brutal. I knew it would be a big change for my son and for me and for the rest of the family. I was not prepared for how emotional it was. For me. And my wife, Cheryl, was a rock. Probably because she saw me being -- Why do you think it hit you so hard? That's one of the reasons I wanted to write the chapter. I thought by writing, I could come to terms with it. I think it had to do with a lot of things. I think it has to do with transition. I think it has to do with mortality. I think it has to do with wanting to keep your kids the way they are forever. And the joy of turning them over to the world. It's great because everybody goes through it. And it feels unique. One of the great things that comes through in this whole book is you did a terrific job of squeezing the most out of every stage of your life. Thank you. That's at its core, what the book is about for everybody. Doesn't matter what you do or where you live or what your job is. Everybody is the architect of their own life. The whole point is living it to the fullest. I take it as a huge complement. Rob Lowe, thanks for coming back again.
This transcript has been automatically generated and may not be 100% accurate.