Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 150 original papers, chapters and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986.
Gandy is a member of the editorial advisory board for the journals Public Library of Science-Medicine (PLoSM), Neurodegenerative Diseases, and Current Alzheimer Research. He is associate editor of the journals Alzheimer Disease and Associated Disorders and Molecular Neurodegeneration, and a consulting editor of The Journal of Clinical Investigation.
From 1996-2006, Gandy was director of the Cold Spring Harbor Laboratories and The Wellcome Trust Annual Summer Course on the Neurobiology of Human Neurological Disorders. In 2000, he became chief organizer for the Cold Spring Harbor Laboratories Bi-Annual Winter Biotechnology Conference on Therapeutic Opportunities in Neurodegenerative Diseases and continues in that role.
Gandy received his M.D. and Ph.D. from the Medical University of South Carolina. He completed an internship in internal medicine at the Columbia University College of Physicians and Surgeons and a residency in Neurology at Cornell University Medical College. Gandy completed postdoctoral training at The Rockefeller University, where, in 1991, he was appointed assistant professor in the laboratory of Paul Greengard, 2000 Laureate of the Nobel Prize in Physiology or Medicine.
From 1992-1997, Gandy was associate Ppofessor of neurology and neuroscience at Cornell University Medical College. From 1997-2001, he was professor of psychiatry and of cell biology at New York University and The Nathan S. Kline Institute for Psychiatric Research.
From 2001-2007, he served as Paul C. Brucker, M.D., Professor of Neuroscience at Jefferson Medical College and founding director of the Farber Institute for Neurosciences. In 2007, he assumed his current post as Mount Sinai professor of Alzheimer's disease research at the Mount Sinai School of Medicine.