"I like you now," Harris told Brown, who was at first a suspect. "Get out of here. Go Home."
Brown appeared on Oprah and wrote his own account in his 2002 book, "No Easy Answers: The Truth Behind Death at Columbine."
Today, in an ironic twist, Brown, who often played video games with the shooters, works in the games division of Lucasfilm's Star Wars outside San Francisco.
"I am perfectly OK since it happened but there's always a little affecting you," Brown said. "I am finally able to do my own thing now. It's definitely a nerd's dream."
For him, the most difficult challenge in healing was the "complete utter lack of support from the community I lived in."
"I basically got thrown out," said Brown. "I wasn't welcome by the friends and families of the victims. People were quite angry with me."
Many survivors, like Ireland -- who recovered from injuries that paralyzed his right side and damaged his language center -- have rebuilt their lives.
Anne Marie Hochhalter, 27, who was shot in the chest and permanently paralyzed from the waist down, dealt with her mother's suicide just 18 months after the shootings. Today, she has a degree in business management and is a part-time manager at a local Bath & Body Works store.
"It helped me, you know [to] believe in faith as well, that I'm here for a reason," she told ABC's Kate Snow. "I have a lot more to give to the world."
Parents of the dead have taken on causes in their children's names. Tom and Linda Mauser, who lost their son Daniel, work for stricter gun control. Brian Rohrbough, father of Daniel, fights to ban abortion; Darrell Scott, father of Rachel, challenges teens and now corporations to help the troubled and lonely.
Not all have happy endings. Marines Lance Cpl. Greg Rund, who survived the Columbine shootings as a freshman, was killed in action on his second tour of duty in Iraq at 21.
Today, on Columbine's 10th anniversary, some things have changed -- the high school library has been destroyed and a memorial to the victims has been dedicated.
And some things haven't. Frank DeAngelis, who counseled countless administrators through their own school shootings, is still principal. He vowed at first to stay until the school's freshmen had graduated and has now pledged to wait for the kindergartners from 1999.
Ireland is poised to publish his own book, "The Boy in the Window," and has been giving motivational speeches at his company, Northwestern Mutual. He and others, like Hochhalter, have forgiven the killers.
At one point, when he was hospitalized, his mother asked, "Do you have any anger toward them?"
"She was harboring a lot of anger," Ireland told ABCNews.com. "To sum it up, I basically said, 'Please forgive them.' She looked and asked, 'Why?' Because they were confused and didn't know what they were doing.
"We have a choice in how we live our lives," he said. "You wake up every single day and have a choice as living as a victim or a victor. When you choose to be a victor, you have so much more positive impact on how people view you and the way you want to live your life."
ABC's information specialist Nicholas Tucker contributed to this report.