Then, in 2001, Ryder was arrested at Saks Fifth Avenue for shoplifting $5,000 worth of clothing and accessories. Though the shoplifting charges took the spotlight, authorities also found eight different painkillers in Ryder's purse, according to The Los Angeles Times.
Police said at the time that she was carrying oxycodone without a prescription, which her lawyer later challenged.
"The attention was what was embarrassing," Ryder said in an 2007 interview with Vogue. "It was the December after Sept. 11. … So much attention was being paid to me, when we had just been attacked, and there was all this really important news going on."
Ryder told Vogue of the events leading up to her arrest. "Two months prior to that, I broke my arm in two places, and the doctor … was giving me a lot of stuff [oxycodone, not to be confused with OxyContin] and I was taking it at first to get through the pain," Ryder said.
"And then there was this weird point when you don't know if you are in pain but you're taking it," Ryder added. "Have you ever taken painkillers? It isn't a reckless [state], like you're out of your head. It's just confusion."
Perry, 39, shot to stardom when he was cast as the sarcastic, yet lovable, Chandler Bing on the hit TV show "Friends."
But at the height of the actor's success, Perry's partying led him to one addiction after another.
"I got into a serious problem with painkillers, a painkiller called Vicodin," the actor said in an interview with Larry King in August 2002. "And that was mostly just to not drink as much as I was. I was getting too hung over, so I tried other things that would try to balance me out."
In 1997, Perry recognized his addiction issues and checked himself into rehab to kick the habit.
"I guess it was around April that I realized the level, the severity of the problem that I was having," Perry admitted in a 1998 interview with CNN. "And I'm really proud that I kind of stepped up to the bat and took care of it. For me, it was a no-brainer. It was just — this is obviously what I have to go do."
But that was not the end of Perry's painkiller abuse. In May 2000, he was hospitalized for pancreatitis, a rare inflammation that can be caused by alcohol and drug abuse. By 2001, he had checked in to the Malibu clinic Promises to keep his addictions at bay.
Now, he says he has kicked the painkillers. He's back to acting and currently working on a new film called "Seventeen Again" with Zac Efron.
Kelly and Jack Osbourne
This brother and sister celebrity pair — offspring of Ozzy "Prince of Darkness" Osbourne — inherited more than their father's fame.
The younger Osbournes followed their father's path of drug use and hard partying. While still young adults both Kelly and her younger brother, Jack, fell victim to painkiller addiction.
In April 2004, Sharon and Ozzy confronted their daughter and had her check into the Promises treatment center in Malibu, Calif.
"She didn't put up a fight," Sharon said on an April 2, 2004 episode of CNN's "Larry King Live."
"It happened so quickly, she didn't have time. It was so much of a shock she said, 'I'll go.'"
The family admits they've had their share of problems with drug use.
"It's a family illness," Ozzy told King. "It's in the genes. In this day and age, the availability of getting drugs is amazing."