Buying Time for Gender-Confused Kids

Medroxyprogesterone is known commercially as Provera, a drug injected once every three months as a birth control medication.

"LHRH has been used for 20 years, medroxyprogesterone probably that long, if not longer, so we know they're safe and effective," says Alan Rogol, a clinical professor of pediatrics at Riley Hospital of the Indiana University School of Medicine and the University of Virginia.

Also, he says, a child will undergo normal puberty following the hormone-blocking treatment, and it is fully reversible should a transgendered child choose not to undergo sex reassignment or transition once they reach adulthood.

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"There is no question that it's reversible, and I'm unequivocal about that," says Rogol.

In addition to delaying the onset of puberty, the hormone-blocking process does help patients avoid unwanted bodily features if they do decide to undergo a sex change upon reaching adulthood. It is the changes of puberty that often cause the most distress for transgendered children.

"We're talking about things that have a profound, significant influence on the child's life," says Diamond.

Male transsexuals can avoid going through menstruation, while female patients can avoid growing body hair or developing a deep voice if they begin sex reassignment once their childhood hormone-blocking regimen ends.

Transitions and Follow-Ups

Although the treatment is reversible, Diamond says that most who reach that point will go on to transition.

"Almost all those who have gender identity disorder continue on to surgery, or at least continue on to transitions," says Diamond.

In his interview with NPR, Spack confirmed that assessment.

"My confidence comes partly because I've yet to see one change their mind and partly because we're using the psychological testing methods the Dutch have perfected, and they've yet to see one person change their mind," he says.

While the procedure allows children to more easily undergo sex reassignment upon reaching adulthood, sex reassignment surgery is controversial.