Most people think of medicines as single-role actors -- one-trick ponies with clearly defined uses.
But some pills can't be so easily pigeonholed. Few would guess, for example, that the erectile dysfunction drug Viagra is also used by doctors to help increase blood flow to other parts of the body when needed, possibly sparing patients the horror of amputation. Or that a drug originally used to treat glaucoma is getting a second life as a means to thicker, more luscious eyelashes.
In many cases, the alternative uses are well-known in the medical community -- though perhaps not among the general public -- and are regularly exploited. For others, the off-label benefits may be less clear.
And while a November article in the journal Pharmacotherapy warned doctors to exercise more scrutiny in their prescription of drugs for purposes other than their primary intended use, it is clear that some of these MacGyvers of the pharmaceutical world are destined for double duty in the years to come.
In a pinch, doctors may look to the erectile dysfunction drug Viagra as a means to increase blood flow to tissues in the body that need it. Such was the case when 20-year-old college sophomore Jamie Schanbaum suffered meningitis and, shortly thereafter, an infection that threatened her fingers and legs.
Dr. Peter Lin, Schanbaum's doctor, who treated her at St. Joseph's hospital outside of Houston, said his team used the drug to see if it would be possible to spare Schanbaum the extensive amputations some physicians suggested as the only way to control the gangrene in her arms and legs.
"Viagra stimulates blood flow," Lin told ABCNews.com. "We wanted as much blood flow to get to the damaged area as possible."
While Viagra's usefulness in this regard has yet to be confirmed, an Australian study this year looked at the possibility that the drug might help increase blood flow to the uterus in pregnant women, which could in turn help developing fetuses receive more oxygen. Other studies have also taken a look at whether the drug could one day be used to increase blood flow to the brains of patients with multiple sclerosis, as well as whether it could help travelers deal with jet lag.
It's a drug whose name has become synonymous with cosmetic treatment. But many forget that Botox -- the most commonly known brand name for botulinum toxin type A -- had its humble start in the treatment of crossed eyes and spastic conditions as early as the 1970s.
However, the reputation of the drug changed forever in 2002 when the U.S. Food and Drug Administration approved it for the treatment of facial frown lines. Injecting the solution into the faces of their patients, doctors could selectively paralyze certain muscles implicated in the formation of wrinkles.
Now, doctors are further stretching the drug's usefulness by treating patients who experience certain type of hyperlacrimation -- in other words, the overproduction of tears in response to certain stimuli.