Lou Gehrig's Disease: Researchers Uncover New Genes

A mammoth team of researchers has uncovered a common biological pathway underlying multiple forms of amyotrophic lateral sclerosis, better known as Lou Gehrig's disease, raising hopes of a new target for therapy. Mutations in a single gene known as UBQLN2 cause hereditary forms of ALS and ALS with dementia, likely through defective degradation of abnormal protein clumps, according to a research letter published online in Nature. Even patients without the UBQLN2 mutation had features of the...Full Story