The legal teams for Knox and Sollecito will make their summations later this week, followed by rebuttals. Knox and Sollecito will get to make statements in their own defense before the six jurors and two judges retire to deliberate. The prosecution needs a majority vote of the jury to keep Knox and Sollecito in prison. An evenly split vote means they would be freed.
The Knox family began the appeals summations with high hopes largely because court appointed experts have harshly criticized the DNA evidence that helped convict Knox and Sollecito in 2009.
"I'm super optimistic," Knox's younger sister Deanna Knox told GMA.
Deanna Knox said her sister does not realize how polarizing her case is.
"The tiny, tiny bit that she sees is when she walks into court," she said. Deanna Knox said her family is acknowledged on the streets with either looks of sympathy or disgust.
"I have had someone spit on me," Deanna Knox told GMA.
She said if Amanda Knox is freed, the family intends to celebrate all of the birthdays and holidays that she missed while in prison.
Watch more on the Amanda Knox trial on "20/20," Friday at 10 p.m. ET.