American unease with double jeopardy could give Knox a "fighting chance" to appeal any extradition in a U.S. court, Christopher L. Blakesley, a professor of international law University of Nevada Las Vegas, told ABC News.com last year.
"There's room to fight extradition," Blakesley said, "and double jeopardy is the spot to fight on…. In the treaty, we functionally accept their system of justice, but it's up to a magistrate to decide whether" the double jeopardy clause of the Constitution was violated and if that trumps the treaty.
Knox's lawyers could also seek to have a prison sentence served in a U.S. prison instead of being sent back to Italy, Zagaris said.
If all else fails, Knox could be saved from extradition if Secretary of State John Kerry intervenes, according to Zagaris.
"She has raised a number of allegations about irregularities in terms of the ways she was apparently unfairly interrogated repeatedly [while in Italian custody] and so forth," Zagaris said.
"She definitely has some arguments because she has already gone through quite an ordeal."