Tonight we're going T see some people directly confronting their deepest fear. Even though more Americans drive while driving than any other form of transportation by far, there is something about... See More
Tonight we're going T see some people directly confronting their deepest fear. Even though more Americans drive while driving than any other form of transportation by far, there is something about boarding a plane where you have no control, you're thousands of feet in the air and your destiny is completely in the hands of somebody else that can really freak some of us out. If you have a truly crippling fear of flying, can it be cured? Byron Pitts introduces us to a man known as "The plane whisperer." Reporter: For many, flying on a plane is a terrifying experience. Oh, my god! It's been 35 years. Reporter: For them the mere thought of being trapped in a plane 30,000 feet in the air, pure white knuckle, chest thumping, I can barely breathe fear, like in this documentary "Fear of flying." Caught on camera. And that's why these men and women are here. We're waiting for him to open the door. Reporter: This retired air force pilot turned therapist is the plane whisperer. This is Ron Nielson's newest class. They have one week to overcome a life of anxiety, which for many is a deep feeling of shame. It's time for me to get on the plane. Reporter: It's estimated 25% of all flyers have some degree of fear. Your chances of dieing in a plane crash is 1 in 60 million, no matter how frequently you fly. In an airplane, I feel like I'm in a tube of death and I'm just waiting for it to fall out of the sky. Reporter: Hollywood has made a profit off of that fear for generations in blockbuster movies like "Flight." From make believe to real-life drama, that Malaysian airline mystery has the globe on edge and those truly afraid of flying in a panic. It makes you not want to fly. Reporter: Sue milgrove is a real estate agent by day, member of a rock band by night and weekends. This mother of three with an mba is fearless in most phases of her life but put her on an air plain -- For some reason my brain tells me I'm going to die. I'll tell the flight attendant I'm scared, I don't want to sit in my seat anymore. Reporter: This is the fourth time she's taken captain Ron's class. Her motivation, pretty simple -- I want to take them to Disney world in Florida. Reporter: Not happening? No. I can't be on the plane four or five hours. And I'm afraid of panicking with them. Then what would happen? Reporter: Part of what sue and others will learn is face your anxiety head on. The plane does a walk-through on a plane they are assured won't take off. How about a big cheer for all of us we made it. Reporter: Information, the captain tells them, is key to overcoming fear. What I find for most people is the furirst thing they need to do is give themselves permission to be afraid. Reporter: In seven days they'll go from a classroom to a real flight, Phoenix to Burbank, California and back home. Sue's going to Las Vegas. If you're going to gamble, why to the gamble. No matter what it takes, I'm going to keep putting myself in that plane. And if I embarrass myself, so be it. Reporter: It's Saturday morning, we're at Phoenix airport, it's the third and final stage of this class. Call it graduation day. But who will pass? I feel a little nervous, anxious. Reporter: Nancy used to fly as part of her job. After a panic attack mid flight, she stopped flying and changed jobs. It's been about six years since I've flown. Reporter: Ross's mcguinnly's fear of flying kept him from attending his parents' own funerals. It's shameful. Reporter: Why? Because others do it so effortlessly. Reporter: He hasn't flown in 35 years. As you'll soon see for Jessica, it will take all's efforts, her husband and her children. She's never flown before. Captain Ron says bring a book, music. Get a drink, restrict your breathing through the draw. If you can constrict your breathing for the first minutes of the flight, you're halfway there. Reporter: Jessica forgot her straw. She took a pill to help her. What happens when you take that much medication? Only take one. What happens is you end up inducing anxiety in yourself. Reporter: Captain Nielson says no alcohol or drugs unless prescribed by a physician. It may add to your anxiety. The thing you should be focusing on is you, okay? I know but I don't want to die. Reporter: Minutes later, much to our surprise, Jessica is calm, actually enjoying herself. Well? I'm doing very well. You're smiling. It wasn't as bad as I guess I thought. I think maybe this is my first time flying so just getting over that hurdle. It's actually beautiful. Reporter: And Jessica's CLA classmate Nancy, the joy of overcoming her fear overwhelms her. Gosh, the world opens up given. Reporter: The landing was as smooth as the flight. Jessica should we say screamed for. In the class. Everyone but Ross. Although he kept quiet the entire flight, he was horrified. The beginning of the end. I'm thinking about driving back. Reporter: The anxiety overwhelming. He decided to drive back to Phoenix, alone in a car for six hours with more regrets, more shame. Oh, lord. Reporter: But remember, it's taken sue four classes to get to this point. It wasn't easy. But she made her flight to Vegas. As for the rest of the flights -- I'd love to take credit for it but it has nothing to do with me. It all has to do with you guys. Reporter: Captain Ron rewards them with a certificate. Once again, you've cheated death by flying with me. Reporter: But the real reward is having traveled from fearful to fearless. It's like a little adventure on the plane. It's just an adventure, that's all it is. People who have a fear of doing this kind of stuff, they feel like they don't have control of things. But you know what, I think the best part is not having the control, not having it. Just letting it go. Reporter: For "Nightline," I'm Byron Pitts in Phoenix.
This transcript has been automatically generated and may not be 100% accurate.