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The debate was expected to feature the most fireworks of any of the three face-to-face confrontations between McCain and Obama, and it did not disappoint.
Earlier this week, McCain's growing deficit in the polls led him to vow to "whip his [Obama's] you-know-what."
McCain, who has cast himself as the "underdog" in the race, has been unable to stop the slide in his poll numbers through the first two debates.
An ABC News/Washington Post poll showed Obama with a 10-point national lead. A New York Times/CBS News poll put that deficit at 14 points.
ABC News' Jake Tapper contributed to this report