"We have many wonderful memories of those days traveling the country and seeing firsthand Elizabeth's great affection for Cate, Jack, and Emma Claire. Today all those moments are rushing back," said Kerry. "The same day our campaign ended at Faneuil Hall, we saw Elizabeth head off to Mass General to confront this terrible disease. America came to know her in a different and even more personal way, as she fought back with enormous grace and dignity. She became an inspiration to so many."
Secretary of State Hillary Clinton also released a statement on Edwards' death, remarking, "America has lost a passionate advocate for building a more humane and just society, for reforming our health care system, and for finding a cure for cancer once and for all."
"But the Edwards family and her legion of friends have lost so much more -- a loving mother, constant guardian, and wise counselor," said Clinton.
The family requests that in lieu of flowers, donations may be made to the Wade Edwards Foundation which benefits the Wade Edwards Learning Lab at www.wade.org.
ABC News' Claire Shipman contributed to this report