Richard Dieter, executive director of the Death Penalty Information Center which opposes the death penalty, agrees.
"Perhaps experts from the medical profession will agree that Ohio has chosen the best available alternative to the risky three-drug process," he said. "But such a conclusion requires an evidentiary and adversarial hearing - not a doormat of blind acceptance."
But victim's rights advocates believe the state has done enough to protect the rights of death row inmates.
Cuyahoga County, Ohio, Prosecutor Bill Mason told ABC News it doesn't matter if justice is brought with one drug or three drugs: "In all cases it is more humane than what these murderers [Kenneth Biros and Romell Broom] did to these innocent victims."
"Broom brutally raped and murdered a 14 year-old child by plunging a knife 7 times into her chest. They ought to have him in a waiting room, and as soon as this procedure is deemed successful [with Biros], they should bring him in and put him on the table before they put the equipment away," he said.
In 2008, the U.S. Supreme Court upheld the constitutionality of a three drug protocol used in Kentucky but the court left open the possibility of other methods being explored.
Biros is now being held in the Lucasville, Ohio, prison and is expected to have his last meal at 4 p.m. today.
He ordered cheese pizza -- with extra cheese, onions, mushrooms, and green peppers -- onion rings, deep fried mushrooms, Doritos, french onion dip, blueberry ice cream, Dr. Pepper and cherry pie.
ABC News' Devin Dwyer contributed to this report.