Palin was reluctant to discuss Levi Johnston, the father of her now nearly 1-year-old grandson, Tripp, saying to Winfrey, "I don't think a national television show is the place to discuss [him]."
Joking that she hears Johnston goes by the name "Ricky Hollywood" now, Palins said that his preparing for a nude appearance in Playgirl magazine -- as "heartbreaking."
"He's on a road that isn't a healthy place to be," Palin said, adding that Johnston is "quite busy with his media tours and he hasn't seen the baby in awhile."
Pressed by Winfrey about the family's plans for Thanksgiving, Palin extended an "open invitation for Levi" to join them for the holiday.
Winfrey also addressed last year's rumors accusing her of snubbing the then-vice presidential nominee and not inviting her to be a guest on her show, a move many of her fans disapproved of at the time.
"What really happened was for the first time in my life I decided to publicly support a candidate and because of that I had made a decision to not have any of the candidates on my show during the campaign and so, for the record, Sarah Palin never asked to be on the show," Winfrey said.
At the time, Palin added, she was unaware of the controversy and had only heard about it in recent weeks. Back then, she said, Winfrey's show "wasn't the center of my universe."
Having resigned from her post as governor in July, Palin was asked by Winfrey what prompted her decision to leave office and whether it was a move calculated to pave the way for the 2012 presidential election.
"I resigned as governor of Alaska because I wasn't going to run for a second term," Palin said.
Asked why she didn't "finish what she started," Palin said, "Alaska was being hampered by my presence there."
Unwilling to entertain discussions about the 2012 election, Palin said she's only thinking about 2010, and that running for president is not on her "radar screen" right now.
"You don't need a title to make a difference," Palin said.