"I'd end the war in Iraq," said Sen. Joe Biden, D-Del. "That would restore the freedom, flexibility and credibility we need to help meet Africa's challenges."
"Giving aid without conditions for reform perpetuates bad policies and poverty," said former New York Republican Mayor Rudy Giuliani. "It's better to give people a hand up rather than a hand out."
"I will fund AIDS treatment and prevention at levels befitting a wealthy and great nation, and establish a goal of eradicating malaria, the No. 1 killer of African children under 5," said Sen. John McCain, R-Ariz.
ONE's political effort is drawing some criticism from AIDS organizations.
"We fully support the ONE effort," said David Bryden of the Global AIDS Alliance, a non-partisan advocacy organization.
"However, they list a number of things that should be first steps for the next president regarding HIV/AIDS ... changing the US approach to HIV prevention is not listed here as one of the first steps," he said.
Bryden argues the Institute of Medicine and other health authorities have indicated the US emphasis on abstinence is not working and not helping the spread of HIV/AIDS in Africa.
"We believe changing this should be one of the first steps," said Bryden.
McCue said Bono has "been a major inspiration for ONE."
"The American election process is a unifying one," said McCue. "ONE Vote '08 is an opportunity to unite and fight hunger, poverty and disease.
"These are American values," she said.
The ONE Vote '08 campaign is consulting with Republican and Democratic political strategists and policy experts to try to build a bipartisan consensus around the issue.
" Unlike so many issues on the '08 agenda, this is not an issue that is on the right and left," said republican strategist Jack Oliver. "It's an issue that is about right and wrong."