For the next two years, Ted lived predominantly as a man, but in a sort of gender no-man's land, a hybrid. He grew his hair out, but would pull it back into a ponytail for work. He would wear men's clothes, but with women's accents. More and more, he felt compelled to become a she.
Four years after the bee sting, Ted officially changed his name to Chloe Alison Prince and began living life as a woman.
Transgender guidelines recommend a transsexual live in their gender of choice for one year before they undergo gender reassignment surgery. The longer period of transition for Ted did not lessen the shock for Rene was she was told that her husband was going to become a woman.
"I didn't want to accept it and begged, pleaded [and] cried, 'Please don't, you can't do this!'" said Rene. "'Honor your mother and father -- the kids need a dad!' There was an inner turmoil within Chloe. There was nothing I could say that would change those feelings."
Feeling as if he had no choice, Ted, now Chloe, forged ahead and in May 2008, flew to Thailand, a country known for their gender reassignment surgeons. Chloe underwent 13 hours of major surgeries. Her male brow bone was shaved down, and she had a vaginoplasty and labiaplasty.
Chloe understands that her choice to transition to living as a woman has not only affected her, but all those around her.
"Transition's not all about yourself. When you decide to transition, everybody else transitions with you. When I chose to be a girl, when I chose to be Chloe, everybody else is forced to make decisions as well," she said.
Would Chloe return home as Rene's husband, or wife? Would she be considered her sons' father or mother? Is she her parents' son or daughter? How did she return to the same job as a different gender? How would her rural Ohio community react to her?
ABC News' "Primetime" spent a year following Chloe Prince and learning firsthand of the everyday struggles that she and her family face due to her transition. Watch "Primetime: Family Secrets" on Tuesday, July 21 to get a glimpse into the Prince home, and watch as, not only a woman, but as a whole family transforms.