To be optimistic, even rookie Mike Glennon had 15 fantasy points in Seattle earlier this season, so it's not impossible for Brees to have one of his big performances as the Saints try to hand Seattle its first home loss since 2011. Rivers will be at home against a Cincinnati team that compiled most of their statistical dominance with Geno Atkins and Leon Hall on the field. Both players are out for the season, and Rivers just had one of the best games of his career.
Do not be afraid to start either, but remember, they're playing against the two best pass defenses, so expectations should be tempered.
It's been a tough season for Spiller, but Atlanta ranks 31st against the pass and 24th against the run. That's why nearly all of the Bills' skill players show up in the favorable table. Buffalo just had a bye week following its best performance of the season. There should be ample scoring opportunities for both Spiller and Jackson in this one: Atlanta allows the ninth-most fantasy points to running backs.
Zac Stacy (minus-1 point)
The Rams' rookie has been very good, with 12-plus fantasy points in his past five outings, but he left Sunday's game with a concussion and he's questionable for Sunday. The 49ers rank 11th against the run, but will be at home after their big win against the Redskins. In the meeting earlier this season, the Rams had 16 handoffs for 22 yards. Stacy did not have a carry, but Benny Cunningham had four for 6 yards.
Alshon Jeffery (plus-1 point)
He's emerged as a good option behind Brandon Marshall this season. He's had at least five targets in every game, and at least 10 targets in five games. Minnesota ranks 21st against No. 2 receivers and allows an average of 61.3 yards per game to them.
Jordan Cameron (plus-1 point)
Cameron has frequently visited this column, ranging from a plus-start to a minus-start to an elite player. Lately he's been absent, with just one touchdown in his past seven games and a total of 10 catches for 65 yards in the past three games combined. Enter the Jacksonville Jaguars, who, despite shutting down Houston, still rank 30th against the pass.
Cameron has been bothered by the musical chairs at quarterback for Cleveland -- a rotation that has bothered everyone not named Josh Gordon -- but he's also dropped some catchable balls. This week is his best chance to return to the end zone, as only the Cardinals allow more fantasy points to tight ends than the Jags.
These are the elite fantasy players for Week 13 not listed in the above tables. You will want to start these players regardless of matchup on a weekly basis.
Two weeks ago we looked at the Broncos-Chiefs matchup. Expectations have changed after the Chiefs suffered injuries to pass-rushers Justin Houston and Tamba Hali. Denver already had success in blocking the pass rush, and Peyton Manning should bounce back with a good game in Sunday's crucial rematch. Tight end Julius Thomas is expected to return, so continue to start all of the Denver skill players. It's not supposed to be too windy.