The cornerback's agent, Peter Schaffer, told ProFootballTalk.com in a telephone interview that Browner will sue the NFL if other attempts at overturning the suspension are unsuccessful.
"We will continue to exhaust all administrative remedies," Schaffer told the website. "If not successful, we will sue the living daylights out of the league."
Browner, whose suspension is effective immediately and without pay, sent out a lengthy statement through his Twitter account after the suspension was announced, sounding resigned that his career with the Seahawks is over.
I want to thank the Seahawks organization for the incredible opportunity they gave me when they took a ... (more) http://t.co/036lrICZRE— Brandon Browner (@bbrowner27) December 19, 2013
Besides thanking the Seahawks organization, Browner maintained his innocence.
"Although I disagree with the circumstances surrounding my suspension, I accept responsibility for all of my actions and I apologize for any that causes any unflattering reflections of my family and the Seahawks," he said in the statement. "I believe in my innocence and will continue to fight with all legal resources available to me to. Go Hawks!!!"
Earlier Wednesday, a league source told ESPN NFL Insider Adam Schefter that Browner had his appeal of the suspension denied.
Browner turned down an opportunity to reduce the ban by nearly three months, according to multiple reports.
The suspension is the second in two seasons for Browner. He was suspended four games last season for violating the league's policy on performance-enhancing substances. He's the second Seahawks player to be suspended for violating the substance-abuse policy this season. Fellow cornerback Walter Thurmond is serving the final week of a four-game suspension.
Browner was injured against Atlanta on Nov. 10 and hasn't played since.
He is in his third season with the Seahawks. He started all 26 games he has played for the Seahawks and has 19 tackles, one interception and 10 passes defensed this season. He was a Pro Bowl selection in 2011 when he had 23 passes defensed and six interceptions, but had not been able to match those numbers in the subsequent two seasons.
His contract is up after this season, and a lucrative contract could await if he can somehow get the decision overturned.
Information from The Associated Press contributed to this report.