Houston, who has not practiced all week, was officially deemed inactive Thursday against the Packers, leaving the Lions with four healthy cornerbacks.
"I'm ready," Slay said this week. "Ain't no second-guessing about me being a starter. If they tell me I'm going to be a starter, I'm going out there with the same mentality I got out there when I wasn't.
"Go out there and compete and beat the guy in front of me."
While quarterback Aaron Rodgers is at least another week away from returning, the Packers got four other starters back for the Thanksgiving game against the Lions.
Barclay missed the last two games because of a knee injury. Perry has missed four of the past five games because of foot and ankle injuries, while Shields missed the last two because of a hamstring injury.
Jolly did not play in last Sunday's game against the Vikings because of a groin injury.
ESPN.com's Rob Demovsky contributed to this report.