Undefeated former U.S. Olympic wrestler Daniel Cormier will replace Gustafsson in the bout, which will headline UFC 178. The pay-per-view event takes place at the MGM Grand Garden Arena in Las Vegas. Officials announced the switch on Wednesday.
Jones (20-1) initially wanted to fight Cormier in his next bout, but the UFC booked a rematch between he and Gustafsson (16-2) instead. The two first met at UFC 165 in a Fight of the Year candidate in September. Jones won via unanimous decision.
The 27-year-old champion has defended his title seven times, a UFC record in that division. He dominated Glover Teixeira in a five-round unanimous decision in April.
Cormier (15-0) is 2-0 since dropping to the light heavyweight division this year. The former heavyweight submitted Dan Henderson via rear-naked choke at UFC 173 on May 24 in Las Vegas.
After defeating Henderson, Cormier, 35, admitted he had fought through a torn LCL and partial ACL tear in his right knee. He was expected to undergo surgery on the knee this month, but will now forego that to pursue a UFC title.
No timetable is currently known for Gustafsson's return.