Samuel kicked off the scoring with a 68-yard receiving touchdown on the opening play, but South Carolina was stifled by Kentucky's defense thereafter and did not score again.
Samuel had five catches for 122 yards and a touchdown, his sixth this season.
South Carolina has lost four straight to Kentucky and will face Texas A&M and Tennessee in road contests in the next four weeks.?
"He's an outstanding teammate and an outstanding friend," quarterback Jake Bentley said, according to The State. "He's going to be hard to replace."
Information from the Associated Press was used in reporting.