Bowe, who caught 57 passes for 673 yards and five touchdowns this season, did not play in Kansas City's season finale against San Diego on Sunday because of a concussion.
"I'm fine,'' said Bowe, who practiced Tuesday. "I had minor headaches. It was nothing big. The coaches were going to rest me anyway, so I had a good time to rest and recover and be fresh for this game. That was the game plan.
"I didn't feel as bad as other people felt when they had a concussion. I just felt a little tired. There wasn't any dizziness or problems with vomit or none of that stuff. It was mainly just fatigue.''
Meanwhile, starting right offensive tackle Eric Fisher (groin injury) will not practice and may not be available to play against the Colts. Fisher would be replaced by Donald Stephenson, who started seven games this season when Fisher or left tackle Branden Albert were out of the lineup.
Outside linebacker Tamba Hali, who has a sore knee, will try to practice later Wednesday.
Albert will be back in the lineup for the first time since Dec. 1, when he injured his knee against Denver. He said he could have played last week, but Chiefs coach Andy Reid decided it wasn't worth risking another injury simply to knock off some rust.
"Whatever Coach decided, I was with,'' Albert said. "I told him and told the rest of the team that I was going to prepare to play. Now it's time to move on from that. I'm playing.''
So is linebacker Justin Houston, who missed the final five games of the regular season after dislocating his right elbow. He's been fitted for the same kind of brace that the Texans' J.J. Watt wears to stabilize his elbow and said he'll be ready to go against Indianapolis.
"The first two days it took some time to get used to," Houston said. "After that, it was OK. I've got all my movement back. It was very frustrating, but as long as we were winning, I was happy with it. I know everybody has their own personal goals, but the team goals are more important and we're still on that journey.''
Information from The Associated Press is included in this report.