Peyton Manning makes Deflategate joke at Rob Lowe's roast

— -- There's never a bad time to toss in a Deflategate joke if you're Peyton Manning. Especially if it's at a roast.

Manning, who took part in Comedy Central's roast of actor Rob Lowe on Monday, managed to throw in a playful dig at the expense of former rival Tom Brady and the New England Patriots.

The joke garnered laughs from all, especially from Lowe, who is a fan of the Indianapolis Colts, the team Manning played for over the first 14 years of his career.