Auburn will move up to the second spot and earn the right to play the unbeaten Seminoles on Jan. 6 in Pasadena, Calif., when the final BCS standings are revealed Sunday night (8:30 p.m. ET, ESPN).
The loss will send the Buckeyes to the Discover Orange Bowl against Clemson, sources said.
Auburn's win against Missouri in the SEC championship game will keep alive the SEC's chances to win an eighth consecutive national championship.
Oklahoma earned an Allstate Sugar Bowl berth, according to sources, after upsetting Oklahoma State. The Sooners will play Alabama, which earned an automatic bid to one of the four BCS bowls by finishing among the top four teams in the BCS standings.
The Rose Bowl Game presented by VIZIO features Big Ten champion Michigan State against Pac-12 champion Stanford. The Spartans are going to the Rose Bowl for the first time since the 1987 season.
This will be the final BCS title game before next year's College Football Playoff, which will involve the top four teams.
Florida State (13-0) has won each of its games by at least 14 points.
"We're not champs yet," coach Jimbo Fisher yelled to his team after it crushed Duke in the ACC championship game on Saturday night.
Florida State will play for the national title for the first time since the 2000 season, and Winston will likely have to stop in New York to pick up the Heisman Trophy before heading to Southern California. The Seminoles will be looking for their first BCS title since 1999.
Auburn has gone from worst in the SEC to first, and a victory away from their second national title in four seasons.
In 2010, it was Gus Malzahn as offensive coordinator for coach Gene Chizik, directing an offense led by junior college transfer quarterback Cam Newton.
Now Malzahn is in his first season as head coach, and junior college transfer quarterback Nick Marshall is directing a seemingly unstoppable running game that gained 545 yards against No. 5 Missouri in Atlanta.
The Tigers (12-1) beat Georgia with the "Prayer at Jordan-Hare" and Alabama with the "Kick Six." On Saturday, maybe that Auburn magic was passed on to Michigan State.
"It's not the SEC conference vs. the ACC conference," Florida State cornerback Lamarcus Joyner said. "It's Florida State vs. Auburn."
Information from The Associated Press was used in this report.