NFL Week 1: The Games You Can't Afford to Miss

Coach Tony Dungy's Colts spent most of the preseason nursing injuries, but the roster is getting healthier. Like the Bengals, the Giants face the league's toughest schedule. Cornerbacks Corey Webster and Sam Madison will have a hard time against Peyton Manning's play-action passing scheme. The Giants hope they have the right configuration at defensive tackle to stop the running of Dominic Rhodes and Joseph Addai. On the other side, Eli Manning looks much more accurate throwing the short passes. He completed just 52.8 percent of his passes last season because he wasn't good on the short stuff. Tom Coughlin added more receiver screens and turns-ins and Eli ate them up. The Giants offensive line has been banged up during the preseason, so it will be a big test going against Dwight Freeney and the Colts quick defensive line.

7. San Diego Chargers at Oakland Raiders (Monday, 10:15 ET, ESPN)

No doubt, this game will scare the Raiders. In 10 career games against the Raiders, LaDainian Tomlinson has averaged 121 rushing yards and four catches. If the Raiders run defense isn't right, Tomlinson, who didn't play a snap during the preseason, could burn them for 200 yards. The Raiders, despite a 4-1 preseason, struggled early in games against good backs, and Tomlinson is arguably the best in the game.

The other player to fear is linebacker Shawne Merriman, who is evolving into one of the most feared defenders in the game. Raiders offensive linemen Langston Walker and Robert Gallery haven't gotten into a blocking groove yet, so Merriman and Shaun Phillips, could have big games. Aaron Brooks takes over for Kerry Collins at quarterback and he will have to keep plays alive against the Chargers' pass rush. The Chargers have perhaps the best defensive front seven in football. Brooks will try to get the ball deep a few times for Randy Moss and to win, the Raiders will need a good performance from halfback LaMont Jordan. Art Shell has made the Raiders a more physical defense, but they will have to show it against a tough, physical Chargers team.

6. Dallas Cowboys at Jacksonville Jaguars

Terrell Owens learned during training camp that the Cowboys aren't necessarily all about Terrell Owens. A hamstring injury sidelined him for most of camp, and it forced him to scramble in the last week to earn a starting job in an unfamiliar offense. Once Owens missed a rehab session and a meeting and was fined $9,500, he got the point. Bill Parcells is in charge of personnel and Drew Bledsoe is comfortable throwing to Terry Glenn and tight end Jason Witten, so Owens needs to work well in the system. He's done that the last few days and has a chance to start if his hamstring hold ups.

At least the Cowboys know they have added to the receiving corps. With the surprise offseason retirement of Jimmy Smith, Jags coach Jack Del Rio isn't sure what he'll get from his receiving corps. Reggie Williams has been in and out of the starting lineup and still hasn't shown the skills that made the Jags use a first-round draft pick on him. Quarterback Byron Leftwich was pounded at times during the preseason looking for receivers to get open. The Cowboys 3-4 defense could be a major problem for the Jaguars. Parcells has assembled one of his best defenses since his Giants days. They are physical, fast, and could make it a tough day for the Jaguars.

5. Baltimore Ravens at Tampa Bay Buccaneers

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