Describing it as a snapshot of her "spontaneous" night in, the photo showed a scantily covered McCain holding an Andy Warhol biography in her hand.
Apparently responding to criticism, McCain quickly followed up her picture with a longer explanation.
"So I took a fun picture not thinking anything about what I was wearing but apparently anything other than a pantsuit I am a slut," she wrote, later adding "I can't even tell you how hurt I am."
Soon after, she considered closing her Twitter account altogether.
"Why I have been considering deleting my twitter account, what once was fun now just seems like a vessel for harassment," she wrote. Later, she escalated her threat.
"Ok I am getting the f*** off twitter, promise not to delete my account until I sleep on it, thank you for the nice words supporters," McCain tweeted.
Finally, she apologized to her followers -- "I have clearly made a huge mistake and am sorry 2 those that are offended" -- but not without one last plug for her new column that launched the same day.
"In the meantime, my new column for The Daily Beast," she wrote, linking to the news site.
In July, Calif. Gov. Arnold Schwarzenegger surprised the Twittersphere when he was seen wielding a two-foot-long knife in a video link posted on Twitter.
In a 27-second video clip, the husky governor addressed his followers while holding a two-foot-long knife.
While the state wrestles with a $26 billion deficit, the celebrity turned Republican governor posted the video as a thank-you to constituents for their ideas on how to pay down the massive deficit, particularly one suggestion to autograph and then auction off state-owned cars.
"Hey guys, I just want to say thanks very much for all the great ideas you're giving me," he said. "You come up with great ideas. Why not just sign the cars since you're a celebrity governor? Sign the cars and sell it for more money. … That's exactly what we're going to do."
According to The Associated Press, Schwarzenegger's spokesman Aaron McLear said the knife was a gift from a friend and arrived Tuesday. He also said the governor actually does intend to sign state vehicles before they're auctioned off in late August. Officials estimate that selling 15 percent of the state's 40,000 government-owned cars could raise about $24 million.
When a reporter asked Schwarzenegger Wednesday whether the video was appropriate, given how seriously the budget cuts are affecting the lives of some Californians, the governor went on the defense.
"Not that I have fun with making the cuts -- they sadden me -- but ... that doesn't mean that you cannot wave a knife around, or to wave your sword around, to get the message across that certain cuts have to be made because it's budget time," Schwarzenegger said during a news conference.
Earlier this summer, author Alice Hoffman caught some flack for getting huffy with a critic via Twitter. Hoffman wasn't too pleased when Roberta Silman said Hoffman's novel "lacked the spark of earlier work" and that "the author doesn't deliver" in a Boston Globe review of her new book, "The Story Sisters."
According to the tweets reprinted on Gawker, she called Silman a "moron" and said "no wonder there is no book section in the Globe anymore."