AMANPOUR (on-screen): And what do you think it's all about?
COONS: I think my grandmother would have said she has a lot of moxie.
AMANPOUR: A good thing?
COONS: I'm not sure why she's running, but that's up for -- that's up to her to explain.
AMANPOUR (voice-over): O'Donnell's support comes mostly from southern Delaware.
(UNKNOWN): My husband and I feel that Christine O'Donnell is not part of the good-old-boy network, and we think she'll bring some fresh ideas and have the courage to stand up for her convictions and to represent the people.
AMANPOUR: Most voters are in the northern part of the state. At the Golden Dove Diner, we spoke to Republican and Tea Party supporter Linda Conway (ph). But she's casting her vote elsewhere.
(UNKNOWN): I feel that the girl has no experience, and for some reason, I just have -- that she's almost like a front for someone. And I just don't feel this young lady has the control and the smarts to get us out of this jam that we're in at this time. And I feel Coons, with his experience, does.
AMANPOUR: We then joined these men, whose company rents linens and uniforms. Like many people across the country, Kenneth Ritoli (ph) told us that he's frustrated and worried about the future.
(on-screen): Do you feel that your children will have it better than your generation, the American dream?
(UNKNOWN): I don't -- I don't know. I really -- and I hate to say that -- I really don't know.
AMANPOUR (voice-over): But all of them told me they see a glimmer of hope after the darkest days of the recession.
(on-screen): Have you had to lay people off?
(UNKNOWN): We did lay off a few people, but since then, we have started rehiring, and things are looking up in our business and getting better.
(BEGIN VIDEO CLIP)
BUSH: I wrote in my book that going out that last Thanksgiving, after George had been elected, but before he was inaugurated governor, and Daddy -- we were all sitting in the den watching football on television over Thanksgiving. And Daddy said, "Who's that over there?" And I said, "That's my husband, Dad. That's George Bush." He said, "You married George Bush?" And I said, "Yes." And then he laughed and said, "I think I'll ask him for a loan."
(END VIDEO CLIP)
AMANPOUR: Funny, but sad, too. Laura Bush reflecting on her father's experience with Alzheimer's. Harold Welch died in 1995, after battling the disease for two years. And more than half of all Americans now know someone with Alzheimer's.
And this morning, we begin a special ABC News series in collaboration with Maria Shriver and the Alzheimer's Association. Together, they've produced "The Shriver Report: A Woman's Nation Takes on Alzheimer's." It's the first to make a compelling connection between Alzheimer's and women. And in a moment, we'll talk with Maria.
But first, how the disease is impacting ordinary American families.
AMANPOUR (voice-over): Every 70 seconds in the United States, someone is diagnosed with Alzheimer's, and experts warn the country is ill-prepared for the growing epidemic.
(UNKNOWN): With the coming of the Baby Boomers, turning of age, starting 2011, almost 80 million of them, we will be seeing a tsunami of -- an increase in Alzheimer's disease.
AMANPOUR: And women are at the epicenter. They make up two-thirds of people who have Alzheimer's and of those who care for people with the disease.