With conditions worsening dramatically in southeast Pennsylvania, Gov. Edward G. Rendell closed the non-toll portions of four interstates at 2 p.m. They include the Schuylkill Expressway (I-76), I-476, I-176, and I-676.
"Other than emergency responders, no one should be driving on Pennsylvania's highways today," Rendell said. "This is a serious storm that will jeopardize the safety of anyone who attempts to travel."
There was a 50-car pileup near Williamsburg, Va. And in New York, the lower level of George Washington Bridge inbound and lower level of Verrazano Narrows Bridge in both directions were closed due to weather conditions.
In Philadelphia, the city shut down its bus service at 5 p.m. because of the deteriorating weather conditions. Bus service will resume at 4 a.m. Thursday. Normally, weekday bus service carries about 500,000 passengers. Ridership Wednesday was about 10 percent normal.
Down the road in Baltimore, Mayor Stephanie Rawlings-Blake banned travel on city streets. Only emergency vehicles, authorized snow plows and power crews are allowed on city streets.
The airports weren't much better.
Airlines at O'Hare International Airport canceled about 600 flights Monday night and Tuesday. For today, operations were slowly getting back to normal but there were still more than 300 flights canceled, according to Gregg Cunningham, a spokesman for Chicago's Department of Aviation.
At least there were no reported delays.
Across town at Midway International Airport, Southwest Airlines started flying again after 24 hours of suspended flights at the airport. Still, Midway had more than 150 flights canceled today.
Airports in New York, Washington, Baltimore and Philadelphia were all virtually closed with the airlines canceling just about every flight in and out of the region. A handful were flying out of New York's three airports, but travelers were advised to check first with their airline.
US Airways canceled 1,571 flights, Continental 900, Delta 900, United 600, Southwest 600, American 500, JetBlue 364, and AirTran 163.
Cancellations will linker into Thursday for certain. American has already canceled 138 flights tomorrow. US Airways canceled 245 flights.
This has not been the most number of flights canceled though.
Most airlines say there have been times when they've had to cancel even more, although the one-two punch of these storms has been particularly brutal on travel.
"I cannot recall any one time where there has been this much disruption to air travel in the [Washington D.C.] metro region," said David Castleveter of the Air Transport Association, the airlines' trade group. "Much of the nation's air travel has been crippled as a result of these treacherous weather events."
Amtrak ran a lighter schedule today along its Northeast Corridor. The national rail company planned service between Washington, New York and Boston but was not running all its normal trains.
The storm also resulted in downed trees and power lines on portions of CSX freight railroad tracks that Amtrak uses south of Washington, resulting in continued service cancelations in Virginia and the Carolinas.
As in the case of the airlines, check with Amtrak before heading to the train station.
With reports from ABC News' Lisa Stark and Ron Claiborne.