Known for: Lively Latin style in the form of nightclubs, rich and spicy Cuban food, and the deco-glam vibe of South Beach, plus a host of cultural offerings that include ballet and art.
Don't miss: The jam-packed scene at Joe's Stone Crab. It doesn't take reservations, but the just-cracked claws dipped in butter are worth the wait -- ditto the tangy Key-lime pie.
Palm Springs, California
Known for: Lush golf courses in the middle of the desert, midcentury-mod architecture (and the oh-so-fab L.A. couples who flock here for it), plus celeb-saturated resorts.
Don't miss: The Palm Springs Aerial Tramway, which travels from the desert floor up 5,800 feet to Mount San Jacinto for hiking or (no joke) snowshoeing and cross-country skiing.
Santa Fe, New Mexico
Known for: Adobe architecture, Native American arts and crafts (turquoise! silver!), and amazing open-air opera performances. Need we say more?
Don't miss: The chilies, widely touted for their aphrodisiac properties (they're said to release endorphins and increase heart rates). Try the Hatch green varieties, which are served fresh on burgers and eggs.
Known for: Deep southern romance that seeps through the red-brick squares, moss-draped oak trees, stately historic houses, and crumbling cemeteries of eerie beauty.
Don't miss: A spring garden tour with the ladies of the Garden Club of Savannah, who show you the secret floral glories that lie behind the brick walls and wrought-iron gates.
Known for: Chic southwestern ambience, world-class golf courses, and posh resorts that launched the nation's spas craze (hot stones, anyone?).
Don't miss: Taking a hot air-balloon ride over the desert at dawn, and watching the sun peek over the saguaro cacti as you float among the early-morning clouds.
Sonoma County, California
Known for: Seriously indulgent inns, miles and miles of vineyards planted with tidy rows of grapes, and restaurants that have become fresh- and organic-food meccas.
Don't miss: A drive along the Sonoma coastline, where waves pound the shore and seals outnumber sunbathers on the beach.