Knox's lawyers have spent much of their defense rejecting prosecution arguments that painted Knox as a sex obsessed "she devil."
The prosecution has used images of Knox and her Sollecito embracing outside the Perugia cottage where Kercher was killed and later at the police station while waiting to be interrogated to reinforce an image of Knox being more interested in sex than her slain roommate.
Knox's lawyers have, instead, compared their client to Jessica Rabbit, the sexy but tender and loving cartoon character in the movie "Who Killed Roger Rabbit."
Defense lawyer Giulia Bongiorno paraphrased Jessica Rabbit's famous line from the movie in which Jessica's draws, "I'm not bad. I'm just drawn that way."
Knox's sisters described their own time in Italy during the trial as "really difficult."
"I'm not used to the cameras in my face," said Ashley, referring to the high level of media interest the case has drawn in Italy.
"It's hard, everything being said in an hour," she said of the family's brief visits with Knox in the prison reception room where the walls have been, at times, sprayed with anti-Knox graffiti, including "Amanda is a whore."
On Monday, with Knox and her family in the courtroom, prosecutors showed the emotion packed autopsy photos of Kercher's nude and bloody body.
"I was surprised and shocked," Deana said of the decision by prosecutors to show the images in court, without warning. "I know it's not something that I would like to see."
During the initial trial and earlier in the appeals hearing, the courtroom had been cleared whenever those photos were introduced. But on Monday, the lawyers did not clear the room, allowing the public to view the photos. The prosecutor later said it was an oversight.
"Amanda told me a lot about Meredith before everything happened and she seemed like a sweet girl," Deana told "GMA." "If that was someone in my family I would never want that to happen so I was a little shocked by his actions to show those pictures."
Knox's lawyers will make their summations on Thursday, followed by summations and statements by Sollecito and Knox.
For Knox's sisters, the final days of the trial are spent looking ahead to what they hope to do with their sister, back home in the U.S.
"Of course hug her and never let go," Ashley said of what she plans to do first if her sister is freed. "And then just catch up on the four years we've missed of her not being there, and do some fun things we both love to do."