The last major snowstorm there was in 1999, dumping about 19 inches. In 1967, 23 inches were dumped on the city.
While the Northeast is no stranger to snow, this storm will be the seventh storm to hit the region in the past 35 days. The string started with the Dec. 26 blizzard that left the region's transportation systems crippled.
New York got snow and some light freezing rain this morning with heavy sleet later tonight into Wednesday.
Last week's snowstorm broke a record in New York City – pushing the monthly total to more than 50 inches -- the snowiest January in more than a century. The average snow total for New York is about 21 inches.
People in the Washington D.C. area are worried about today's storm too.
At Ann Simmons Knight's home in Silver Spring, Md., the power has just been restored after last week's storm, but she's worried about today's forecast of snow, sleet and ice.
"You worry about no power. You worry about trees coming down," Knight told ABC News Radio. "You worry about emergency vehicles not being able to get in because of trees across the road."
North of Philadelphia into Connecticut, a winter storm warning is in place for significant ice accumulation.
As the storm headed east, it left in its wake mangled cars caught in weather-related accidents.
A bus full of students flipped over on an icy narrow lane in Kansas City.
In Colorado, emergency crews were dispatched to help motorists who lost control and tumbled off a highway.
Crews in Oklahoma report "blizzard-like" conditions on the roads, with stalled vehicles all around the state. Transportation departments in Missouri and Illinois have interactive highway maps showing the current road conditions and closures.
ABC News' Sam Champion and the Associated Press contributed to this report.