they are lining up all over america tonight for a giant, $300 million powerball jackpot. We here at abc news will do a story one designed to make you feel that you almost certainly will not win this... See More
they are lining up all over america tonight for a giant, $300 million powerball jackpot. We here at abc news will do a story one designed to make you feel that you almost certainly will not win this thing. Here's abc's susan saulny. Reporter: Everybody wants to be a lottery winner. God, vishnu, allah, whoever's up there, I beg you! Reporter: And tonight, powerball dreams, to the tune of $300 million may be coming true. But, winner beware, that lucky ticket could change your life, for the worse. 44% of people who win the lottery -- within five years, they've blown through all their winnings. How do you feel winning all that money? Reporter: Reality is, the winner's circle is home to many horror stories. Art will imitate life in a new abc series, "lucky 7," about workers in queens who win a lottery in an office pool. Diamonds! Pink, blue or white? Reporter: Then face the unexpected. Big winner, jack wittiker has a lesson from real life. It certainly has been a curse to me. Reporter: Whittiker won the largest payout in history in 2002, but came to know hardship and loss. Some advice from dave honeywell who won $217 million in february -- don't tell anyone. And don't get it out until you have things, your matters in hand. He said winners should shut down facebook pages and keep a small circle of trusted friends and relatives. More advice from experts -- don't trust anyone trying to sell you something and hire an account aebt and lawyer. They'll be your new best friends.
This transcript has been automatically generated and may not be 100% accurate.