Jennifer Aniston and Chelsea Handler. Credit: Tammie Arroyo/AP.

All those rumors about Jennifer Aniston being smack-talking diva are true. When she's playing one, anyway. Aniston mocks herself in a new clip from Chelsea Handler's "After Lately," in which she slams the E! comic to her staff for having bad hygiene and not being funny.

In real life, Aniston and Handler are tight. At Glamour's Women of the Year awards in November, the former "Friends" star declared, "I'm madly in love with the one and only Chelsea Handler!"